EndoPAT (Peripheral Arterial Tone)

EndoPAT (Peripheral Arterial Tone) evaluation is a non-invasive test that looks to see if the lining of the arteries are damaged. Endothelial cells line the inner walls of the heart and blood vessels. Damage to these cells is the earliest clinically detectable stage of cardiovascular disease we can observe. Normal endothelial function protects blood vessels from atherosclerosis, hardening of the arteries, or plaque buildup.

The EndoPAT is used in advanced research programs at institutes such as the Framingham Heart Study, The Mayo Clinic, Harvard Medical School, Mount Sinai, New York, Cedars-Sinai, Johns Hopkins, Emory and many more.

Endothelial Dysfunction

EndoPAT

For more than a decade endothelial dysfunction has been recognized by the medical community as the critical junction between risk factors and clinical disease. It is the earliest detectable stage of cardiovascular disease. Furthermore, it is treatable, and unlike the atherosclerotic plaque which it causes, is even reversible.

EndoPAT is the leading medical device for noninvasive endothelial function assessment.It is FDA-cleared (USA regulation), CE-marked (European regulation), SHONIN-cleared (Japanese regulation) and used in preeminent clinical institutions, research centers and Pharmaceutical clinical phase studies in over 40 countries with thousands of tests performed every month. It is incorporated into numerous multi-center and population-based studies such as the Framingham Heart Study. Research using EndoPAT has yielded more than 100 articles in peer-reviewed journals and abstracts. It is becoming widely recognized as the standard method for endothelial function assessment. Some of the features that make EndoPAT appealing are its ease of use, user-independence and immediate, automatically calculated test results. It provides clinicians with areliable and reproducible index of endothelial function in a 15-minute, office-based test.

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EndoPAT has been extensively reviewed in scientific publications. It is based on non-invasive Peripheral Arterial Tone (PAT) signal technology described below. It measures endothelium-mediated changes in vascular tone using unique bio-sensors placed on the fingertips. These changes in arterial tone are elicited by creating a down-stream hyperemic response induced by a standard 5-minute occlusion of the brachial artery. Measurements from the contra-lateral arm are used to control for concurrent non-endothelial dependent changes in vascular tone. The automatically calculated result is an index of endothelial function.

Assessing Endothelial Vasodilator Function
with the Endo-PAT 2000 (Stanford University)

 
Source: www.JoVE.com

EndoPAT on The View

 
Source: www.JoVE.com

EndoPAT on The View

 
Source: www.JoVE.com
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